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Microbiology Jeopardy

Gram stains to cytokine storms: a microbiology exam review built for team play. Make your own copy for free and buzz in over phones, no clickers required.

6 categories · 30 clues · Final Jeopardy · everyone buzzes in from their phone

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Bacterial Structure

  1. $200

    This rigid outer layer, made of peptidoglycan, gives most bacteria their shape and protects against osmotic pressure.

    What is the cell wall?

  2. $400

    This whip-like appendage rotates like a propeller to move a bacterial cell through liquid.

    What is a flagellum?

  3. $600

    This small, circular piece of DNA, separate from the main bacterial chromosome, often carries antibiotic resistance genes.

    What is a plasmid?

  4. $800

    This tough, dormant structure allows certain bacteria, such as Bacillus and Clostridium species, to survive extreme heat and dryness.

    What is an endospore?

  5. $1,000

    This gel-like layer outside the cell wall of some bacteria helps them evade phagocytosis by immune cells.

    What is a capsule?

Viruses

  1. $200

    This infectious particle consists only of genetic material inside a protein coat and cannot reproduce outside a host cell.

    What is a virus?

  2. $400

    This protein shell encloses a virus's genetic material.

    What is the capsid?

  3. $600

    This type of virus infects specifically bacteria.

    What is a bacteriophage?

  4. $800

    This viral replication cycle immediately produces new virus particles and lyses the host cell.

    What is the lytic cycle?

  5. $1,000

    This enzyme, carried by retroviruses like HIV, converts viral RNA into DNA inside the host cell.

    What is reverse transcriptase?

Growth and Control

  1. $200

    This laboratory technique separates a mixed bacterial sample on a plate so individual colonies can be isolated.

    What is the streak plate method?

  2. $400

    This process uses pressurized steam at high temperature to kill all microorganisms and spores on equipment.

    What is autoclaving?

  3. $600

    This four-phase pattern of population growth in a closed bacterial culture includes lag, log, stationary, and death phases.

    What is the bacterial growth curve?

  4. $800

    This term describes an agent that inhibits the growth of microorganisms without necessarily killing them.

    What is a bacteriostatic agent?

  5. $1,000

    This temperature range, favored by most human pathogens and matching human body temperature, defines this category of bacteria.

    What is the mesophilic range?

Immunology

  1. $200

    This type of white blood cell engulfs and digests pathogens through phagocytosis.

    What is a macrophage?

  2. $400

    This protein, produced by B cells, binds specifically to an antigen to help neutralize it or mark it for destruction.

    What is an antibody?

  3. $600

    This type of immunity develops after exposure to a pathogen or vaccine and involves memory cells for a targeted response.

    What is adaptive immunity?

  4. $800

    This class of white blood cells, including helper and cytotoxic types, coordinates and carries out cell-mediated immunity.

    What are T cells?

  5. $1,000

    This excessive, body-wide release of inflammatory signaling proteins can cause severe tissue damage during a serious infection.

    What is a cytokine storm?

Pathogens and Disease

  1. $200

    This rod-shaped bacterium, spread through respiratory droplets, causes tuberculosis.

    What is Mycobacterium tuberculosis?

  2. $400

    This spiral-shaped bacterium causes Lyme disease and is transmitted by tick bites.

    What is Borrelia burgdorferi?

  3. $600

    This sexually transmitted bacterium causes gonorrhea.

    What is Neisseria gonorrhoeae?

  4. $800

    This protozoan parasite, transmitted by Anopheles mosquitoes, causes malaria.

    What is Plasmodium?

  5. $1,000

    This gram-positive bacterium produces a potent neurotoxin that causes tetanus.

    What is Clostridium tetani?

Stains and Lab Skills

  1. $200

    This staining procedure divides most bacteria into two groups, purple and pink, based on cell wall structure.

    What is the Gram stain?

  2. $400

    This dye, retained by acid-fast organisms like Mycobacterium, resists decolorization with acid alcohol.

    What is carbolfuchsin?

  3. $600

    This gram-positive cell wall component, a thick layer that retains crystal violet, distinguishes gram-positive from gram-negative bacteria.

    What is peptidoglycan?

  4. $800

    This lab technique uses a series of biochemical reactions to identify an unknown bacterial species.

    What is a biochemical test?

  5. $1,000

    This optical instrument, using two lenses and visible light, is the standard tool for viewing bacteria in a microbiology lab.

    What is a compound light microscope?

Final Jeopardy — History of Microbiology

Returning from vacation in 1928, this Scottish bacteriologist noticed a Penicillium mold killing staphylococci on one of his culture plates.

Who is Alexander Fleming?

How to run this board

Micro courses bury students in genus names and stain results, and retrieval practice is the honest fix. The six columns here span bacterial structure, viruses, growth and control, immunology, pathogens and disease, and lab techniques, so the board doubles as a syllabus checklist.

Before a lab practical, run it in the lab itself with bench groups as teams. The board goes on the monitor and phones handle the buzzing.

Tip: when a team names a pathogen, ask for the disease it causes as a follow-up for the same points. Pairing organism and disease is what the exam really wants.

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